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Small: molecular mechanism, characterization technology and application in nano security research of nano materials biotransformation

wallpapers News 2020-08-07
The biosafety of

artificial nanomaterials is a fundamental issue related to the sustainable development of nanotechnology. The complex physical chemical properties of nanomaterials determine the diversity of their biological effects. The interaction between nanomaterials biomolecules after entering the biological system that is the biotransformation of nanomaterials is an important molecular initiation event leading to toxic effects. In recent years

have made important breakthroughs in the research of nano biotransformation some typical biotransformation processes have been deeply analyzed. For example Gao Meng et al. Found that the monatomic holes on the surface of two-dimensional snse nanomaterials have high activity which can simulate the catalytic performance of cell dehydrogenase catalyze the dehydrogenation of lactic acid ethanol malic acid glycerol triphosphate other substrates. Dehydrogenation of these organic compounds involves the key steps of cellular energy metabolism is closely related to the metabolism of intracellular sugars lipids amino acids immune regulation tumorigenesis (Gao et al Angewte Chemie International Edition 2020 593618-3623). Zheng Huizhen et al. Found that graphene oxide lanthanum oxide composite can dephosphorylate peroxidate the phospholipid on the bacterial membrane after contacting with the bacterial membrane thus destroying the bacterial phospholipid layer peptidoglycan layer. At the same time rare earth nanoparticles are transformed into sea urchin like hexagonal phase LaPO4 (Zheng et al ACS Nano 2019 13 11488-11499). Cai Xiaoming et al. Established a multi-dimensional evaluation method of nano biological effects by using protein metabonomics technology used this method to evaluate the multiple structure-activity relationship between seven basic physical chemical properties of nano iron oxide six biological effects. It was found that the inflammatory effect was mainly determined by the aspect ratio of iron oxide nanorods the surface activity was the main factor affecting cell migration. Nano iron oxide enters cells through endocytosis destroys lysosomes induces cathepsin B release NLRP3 inflammasome activation caspase-1 cleaves pro-il-1 β releases inflammatory factors. These biological mechanisms have been further verified in mouse models (CAI et al nature communications 2018 9 4416).

this review systematically discussed the following hot issues in the research of nano biosafety: 1) nano biological interaction interface under different exposure pathways the influence of exposure pathways on the bioconversion biological effects of nano materials the calculation methods of animal dose cell experimental dose in nano safety detection; 2) molecular mechanism of nano materials bioconversion nano particles (3) characterization methods of bioconversion of nanomaterials including optical electron microscopy X-ray mass spectrometry Raman spectroscopy the advantages problems of characterization techniques in the study of nano bioconversion; (4) human beings From the perspective of nano biotransformation the safety design methods of surface coating morphology control doping surface passivation were discussed. Finally the significance of nano biotransformation research was discussed in view of the bottleneck problems in nano safety assessment nano medicine research the future research direction was prospected.


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