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Advanced materials: Porous Au@Rh Bimetallic nuclear nanostructures alleviate tumor hypoxia and are used in bimodal imaging and photodynamic therapy

wallpapers News 2020-08-21

with the rapid growth of tumor the abnormal vascular network in tumor leads to the oxygen supply is difficult to meet its metabolic needs resulting in tumor hypoxia microenvironment. As an oxygen dependent therapy the efficiency of photodynamic therapy (PDT) is usually reduced due to the hypoxia of tumor itself. So far researchers have taken a variety of methods to solve the problem of tumor hypoxia such as using perfluorocarbon as oxygen carrier to directly transport oxygen to the tumor site or using nano materials such as C3N4 or Cao 2 to decompose in situ to produce oxygen to improve the problem of tumor hypoxia but the above methods still have limitations. Another solution is to release tumor hypoxia microenvironment by catalyzing the decomposition of endogenous H2O2 to produce oxygen. Common nano catalysts include catalase loaded PLGA nanoparticles MnO2 based nanomaterials. Although these nanomaterials can catalyze hydrogen peroxide to produce oxygen their effective application in vivo is facing great challenges due to the instability of catalase the acid responsiveness of MnO2 nanoparticles. Therefore it is of great significance to develop new nano materials to effectively produce oxygen in situ improve the hypoxic environment of tumor to improve the efficiency of PDT.

in view of this Professor Hong Jun Wang's team of Stevens Institute of technology in the United States has prepared a novel porous gold rhodium bimetallic core-shell nanostructure using polymer micelles as templates( Au@Rh )。 This kind of nano material shows the activity similar to catalase which can effectively catalyze the endogenous hydrogen peroxide of tumor to produce oxygen. Due to the large pore size (~ 10 nm) this porous material can contain a large amount of photosensitizer indocyanine green (ICG). In addition tumor cell membrane is wrapped on the surface of nanoparticles to achieve homologous targeting of tumor cells. In vivo in vitro studies showed that Au@Rh-ICG-CM This kind of nano system has mild photothermal conversion ability good tumor endogenous hydrogen peroxide catalytic ability high drug entrapment rate tumor targeting function can realize tumor fluorescence photoacoustic imaging mild photothermal enhanced photodynamic therapy.

are related to "a group" Au@Rh Bimetallic core – shell nanostructure as an H2O2 ‐ driven oxygen generator to associate tumor hypoxia for simultaneous bimodal imaging enhanced photodynamic therapy " published in advanced materials( DOI:10.1002/adma.202001862 )It's on.


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